PFAS Navigating Analytical Method Options, Part 3

The complex chemistry of PFAS necessitates multiple analytical approaches, as no single method performs optimally across all target analytes and matrices. Since publishing Method 537 in 2008 (updated in 2018) for 18 PFAS in drinking water, the USEPA expanded its methodological framework with Method 533 in November 2019, specifically developed for shorter-chain PFAS using improved analytical techniques. These drinking water methods exhibit both important commonalities and critical differences.

For non-potable water and solid matrices, EPA Method 1633A has emerged as the industry standard, analyzing 40 PFAS across all routine environmental matrices, while superseding earlier analytical approaches such as various ASTM and SW-846 methods. The Department of Defense has further strengthened analytical protocols by establishing rigorous quality assurance criteria for PFAS testing in their Quality Systems Manual (QSM). Simultaneously, environmental laboratories have developed specialized methodologies over the past two decades to analyze a broad range of PFAS in both traditional environmental samples and challenging matrices including air, biological specimens, consumer products, and food.

This presentation will introduce non-targeted technologies—TOP Assay, TOF, and Non-Target Analysis—highlighting how these approaches complement established targeted methodologies.

By comparing current analytical options and examining developing techniques, we aim to provide practitioners with a clear framework for selecting appropriate methodological approaches for their specific PFAS assessment needs.

Original Airdate: Tuesday, June 10, 2025
 
Length: 60 minutes 

Presenter: Taryn McKnight - Eurofins Environment Testing